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G-protein activation by a metabotropic glutamate receptor. Seven AB, Barros-Álvarez X et al. Nature. 2021 Jul 15;595(7867):450-454.

Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes. Zhang X, Belousoff MJ et al. Cell Rep. 2021 Jul 13;36(2):109374.

Nuclear cGAS: guard or prisoner? de Oliveira Mann CC, Hopfner KP. EMBO J. 2021 Jul 12:e108293.

Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants. Xu J, Xu K et al. Nature. 2021 Jul 8;595(7866):278-282.

Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity. Gupta TK, Klumpe S et al. Cell. 2021 Jul 8;184(14):3643-3659.e23.

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News

May 28, 2021

The ChimeraX 1.2 production release is available. See the change log for what's new.

May 6, 2021

We're looking for somebody to join the ChimeraX development team! Please see the job posting for details.

December 11, 2020

The RBVI wishes you a safe and happy holiday season! See our 2020 card and the gallery of previous cards back to 1985.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325 and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

GPCR conservation coloring tube helices

Coloring by Sequence Conservation

Atomic structures, including cartoons and molecular surfaces, can be colored by the conservation in an associated multiple sequence alignment. The figure shows a structure of the β2-adrenergic receptor signaling complex (PDB 3sn6) with receptor cartoon colored blue→white→red from least conserved to most conserved. The β2-adrenergic receptor is a member of the class A G-protein-coupled receptor superfamily. Conservation was calculated from a superfamily alignment from PASS2 using the entropy-based measure from AL2CO (included with ChimeraX courtesy of Pei and Grishin). The sequence alignment and step-by-step instructions for making this image are given in the Coloring by Sequence Conservation tutorial.

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Example Image

cyclodextrin pore

Cyclodextrin Pore

The outer-membrane protein CymA admits bulky molecules into the periplasmic space of Klebsiella oxytoca. Here, CymA (PDB 4d5d chain A) is depicted in a style reminiscent of a diagnostic X-ray, with transparent molecular surface and β-strand “ribs” in white. The protein has ingested α-cyclodextrin (top) and β-cyclodextrin (bottom), bound at the entry site and near the exit, respectively. Cyclodextrin carbon atoms are shown in blue-gray and oxygen atoms in brick red. For image setup, see the command file xray.cxc.

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