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UCSF ChimeraX Citations

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Selected Citations

The tethered peptide activation mechanism of adhesion GPCRs. Barros-Álvarez X, Nwokonko RM et al. Nature. 2022 Apr 28;604(7907):757–762.

Structural basis for the tethered peptide activation of adhesion GPCRs. Ping YQ, Xiao P et al. Nature. 2022 Apr 28;604(7907):763–770.

Mechanism of RNA polymerase I selection by transcription factor UAF. Baudin F, Murciano B et al. Sci Adv. 2022 Apr 22;8(16):eabn5725.

Structure of active human telomerase with telomere shelterin protein TPP1. Liu B, He Y et al. Nature. 2022 Apr 21;604(7906):578–583.

Structural basis of lipopolysaccharide maturation by the O-antigen ligase. Ashraf KU, Nygaard R et al. Nature. 2022 Apr 14;604(7905):371–376.

Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation. Glassman CR, Tsutsumi N et al. Science. 2022 Apr 8;376(6589):163-169.

Differential assembly diversifies GABAA receptor structures and signalling. Sente A, Desai R et al. Nature. 2022 Apr 7;604(7904):190–194.

Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models. Huang HY, Liao HY et al. Sci Transl Med. 2022 Apr 6;14(639):eabm0899.

Architecture and antigenicity of the Nipah virus attachment glycoprotein. Wang Z, Amaya M et al. Science. 2022 Mar 25;375(6587):1373-1378.

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity. Meng B, Abdullahi A et al. Nature. 2022 Mar 24;603(7902):706–714.

Recovery of particulate methane monooxygenase structure and activity in a lipid bilayer. Koo CW, Tucci FJ et al. Science. 2022 Mar 18;375(6586):1287-1291.

Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria. Saito K, Kratzat H et al. Nature. 2022 Mar 17;603(7901):503-508.

FliL ring enhances the function of periplasmic flagella. Guo S, Xu H et al. Proc Natl Acad Sci USA. 2022 Mar 15;119(11):e2117245119.

Structural basis of human telomerase recruitment by TPP1-POT1. Sekne Z, Ghanim GE et al. Science. 2022 Mar 11;375(6585):1173-1176.

Structural basis for mismatch surveillance by CRISPR-Cas9. Bravo JPK, Liu MS et al. Nature. 2022 Mar 10;603(7900):343-347.

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody. Yin W, Xu Y et al. Science. 2022 Mar 4;375(6584):1048-1053.

Structural architecture of the human NALCN channelosome. Kschonsak M, Chua HC et al. Nature. 2022 Mar 3;603(7899):180-186.

Structure of a thylakoid-anchored contractile injection system in multicellular cyanobacteria. Weiss GL, Eisenstein F et al. Nat Microbiol. 2022 Mar;7(3):386-396.

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement. McCallum M, Czudnochowski N et al. Science. 2022 Feb 25;375(6583):864-868.

2.4-Å structure of the double-ring Gemmatimonas phototrophica photosystem. Qian P, Gardiner AT et al. Sci Adv. 2022 Feb 18;8(7):eabk3139.

Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin. Wang Z, Grange M et al. Science. 2022 Feb 18;375(6582):eabn1934.

Activation mechanism of PINK1. Gan ZY, Callegari S et al. Nature. 2022 Feb 10;602(7896):328–335.

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. Dejnirattisai W, Huo J et al. Cell. 2022 Feb 3;185(3):467-484.e15.

Cellular homologs of the double jelly-roll major capsid proteins clarify the origins of an ancient virus kingdom. Krupovic M, Makarova KS, Koonin EV. Proc Natl Acad Sci USA. 2022 Feb 1;119(5):e2120620119.

Drug discovery in the era of cryo-electron microscopy. Robertson MJ, Meyerowitz JG, Skiniotis G. Trends Biochem Sci. 2022 Feb;47(2):124-135.

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry. Park YJ, De Marco A et al. Science. 2022 Jan 28;375(6579):449-454.

Architecture of the chloroplast PSI-NDH supercomplex in Hordeum vulgare. Shen L, Tang K et al. Nature. 2022 Jan 27;601(7894):649–654.

Multiple conformations of trimeric spikes visualized on a non-enveloped virus. Zhang Y, Cui Y et al. Nat Commun. 2022 Jan 27;13(1):550.

Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Cui Z, Li X et al. Nat Commun. 2022 Jan 21;13(1):432.

Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism. Noddings CM, Wang RY et al. Nature. 2022 Jan 20;601(7893):465-469.

Cryo-EM structures of amyloid-β 42 filaments from human brains. Yang Y, Arseni D et al. Science. 2022 Jan 14;375(6577):167-172.

Single particle cryo-EM structure of the outer hair cell motor protein prestin. Butan C, Song Q et al. Nat Commun. 2022 Jan 12;13(1):290.

Structural basis of branch site recognition by the human spliceosome. Tholen J, Razew M et al. Science. 2022 Jan 7;375(6576):50-57.

Structure of pathological TDP-43 filaments from ALS with FTLD. Arseni D, Hasegawa M et al. Nature. 2022 Jan 6;601(7891):139–143.

Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants. McCallum M, Walls AC et al. Science. 2021 Dec 24;374(6575):1621-1626.

A conserved mechanism for regulating replisome disassembly in eukaryotes. Jenkyn-Bedford M, Jones ML et al. Nature. 2021 Dec 23;600(7890):743–747.

A unified evolutionary origin for the ubiquitous protein transporters SecY and YidC. Lewis AJO, Hegde RS. BMC Biol. 2021 Dec 15;19(1):266.

Nuclear pores dilate and constrict in cellulo. Zimmerli CE, Allegretti M et al. Science. 2021 Dec 10;374(6573):eabd9776.

How to build a ribosome from RNA fragments in Chlamydomonas mitochondria. Waltz F, Salinas-Giegé T et al. Nat Commun. 2021 Dec 9;12(1):7176.

Structural insights into Ubr1-mediated N-degron polyubiquitination. Pan M, Zheng Q et al. Nature. 2021 Dec 9;600(7888):334–338.

Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape. Mast FD, Fridy PC et al. eLife. 2021 Dec 7;10:e73027.

Mechanism for the activation of the anaplastic lymphoma kinase receptor. Reshetnyak AV, Rossi P et al. Nature. 2021 Dec 2;600(7887):153–157.

Structure and desensitization of AMPA receptor complexes with type II TARP γ5 and GSG1L. Klykov O, Gangwar SP et al. Mol Cell. 2021 Dec 2;81(23):4771-4783.e7.

Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein. Tai L, Zhu G et al. Proc Natl Acad Sci USA. 2021 Nov 30;118(48):e2112703118.

Molecular architecture of black widow spider neurotoxins. Chen M, Blum D et al. Nat Commun. 2021 Nov 29;12(1):6956.

Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding. Solon AL, Tan Z et al. Sci Adv. 2021 Nov 19;7(47):eabj9812.

Target site selection and remodelling by type V CRISPR-transposon systems. Querques I, Schmitz M et al. Nature. 2021 Nov 18;599(7885):497-502.

Architecture and assembly mechanism of native glycine receptors. Zhu H, Gouaux E. Nature. 2021 Nov 18;599(7885):513-517.

Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2. Tillinghast J, Drury S et al. Mol Cell. 2021 Nov 18;81(22):4650-4662.e4.

The structure of neurofibromin isoform 2 reveals different functional states. Naschberger A, Baradaran R et al. Nature. 2021 Nov 11;599(7884):315-319.

Cryo-EM structures of PI3Kα reveal conformational changes during inhibition and activation. Liu X, Yang S et al. Proc Natl Acad Sci USA. 2021 Nov 9;118(45):e2109327118.

Structural features of nucleosomes in interphase and metaphase chromosomes. Arimura Y, Shih RM et al. Mol Cell. 2021 Nov 4;81(21):4377-4397.e12.

Distinct allosteric mechanisms of first-generation MsbA inhibitors. Thélot FA, Zhang W et al. Science. 2021 Oct 29;374(6567):580-585.

Structure of Venezuelan equine encephalitis virus in complex with the LDLRAD3 receptor. Basore K, Ma H et al. Nature. 2021 Oct 28;598(7882):672–676.

Structures of full-length glycoprotein hormone receptor signalling complexes. Duan J, Xu P et al. Nature. 2021 Oct 28;598(7882):688–692.

Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD. Errico JM, Zhao H et al. Cell Rep. 2021 Oct 26;37(4):109881.

Structure of a human replisome shows the organisation and interactions of a DNA replication machine. Jones ML, Baris Y et al. EMBO J. 2021 Oct 25:e108819.

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study. Hastie KM, Li H et al. Science. 2021 Oct 22;374(6566):eabh2315.

Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies. Lempp FA, Soriaga LB et al. Nature. 2021 Oct 14;598(7880):342-347.

Reconstitution of an intact clock reveals mechanisms of circadian timekeeping. Chavan AG, Swan JA et al. Science. 2021 Oct 8;374(6564):eabd4453.

Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism. Rao Q, Han L et al. Nat Struct Mol Biol. 2021 Oct;28(10):799-810.

Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Zhang K, Julius D, Cheng Y. Cell. 2021 Sep 30;184(20):5138-5150.e12.

Structure of human cytomegalovirus virion reveals host tRNA binding to capsid-associated tegument protein pp150. Liu YT, Strugatsky D et al. Nat Commun. 2021 Sep 17;12(1):5513.

SEQCROW: A ChimeraX bundle to facilitate quantum chemical applications to complex molecular systems. Schaefer AJ, Ingman VM, Wheeler SE. J Comput Chem. 2021 Sep 15;42(24):1750-1754.

Regulation of human mTOR complexes by DEPTOR. Wälchli M, Berneiser K et al. eLife. 2021 Sep 14;10:e70871.

Nucleolar maturation of the human small subunit processome. Singh S, Vanden Broeck A et al. Science. 2021 Sep 10;373(6560):eabj5338.

Structural basis for piRNA targeting. Anzelon TA, Chowdhury S et al. Nature. 2021 Sep 9;597(7875):285-289.

Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme. Liu C, Shi W et al. Science. 2021 Sep 3;373(6559):1142-1146.

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape. Starr TN, Czudnochowski N et al. Nature. 2021 Sep 2;597(7874):97-102.

Broad sarbecovirus neutralization by a human monoclonal antibody. Tortorici MA, Czudnochowski N et al. Nature. 2021 Sep 2;597(7874):103-108.

A topological switch in CFTR modulates channel activity and sensitivity to unfolding. Scholl D, Sigoillot M et al. Nat Chem Biol. 2021 Sep;17(9):989-997.

Accurate prediction of protein structures and interactions using a three-track neural network. Baek M, DiMaio F et al. Science. 2021 Aug 20;373(6557):871-876.

Structural basis for target site selection in RNA-guided DNA transposition systems. Park JU, Tsai AW et al. Science. 2021 Aug 13;373(6556):768-774.

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants. Wang L, Zhou T et al. Science. 2021 Aug 13;373(6556):eabh1766.

Structural insights into how Prp5 proofreads the pre-mRNA branch site. Zhang Z, Rigo N et al. Nature. 2021 Aug 12;596(7871):296-300.

SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern. McCallum M, Bassi J et al. Science. 2021 Aug 6;373(6555):648-654.

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Gobeil SM, Janowska K et al. Science. 2021 Aug 6;373(6555):eabi6226.

Building better barrels – β-barrel biogenesis and insertion in bacteria and mitochondria. Diederichs KA, Buchanan SK, Botos I. J Mol Biol. 2021 Aug 6;433(16):166894.

Structural basis of human separase regulation by securin and CDK1-cyclin B1. Yu J, Raia P et al. Nature. 2021 Aug 5;596(7870):138-142.

Structural basis of early translocation events on the ribosome. Rundlet EJ, Holm M et al. Nature. 2021 Jul 29;595(7869):741-745.

CryoEM structure of the Nipah virus nucleocapsid assembly. Ker DS, Jenkins HT et al. PLoS Pathog. 2021 Jul 16;17(7):e1009740.

G-protein activation by a metabotropic glutamate receptor. Seven AB, Barros-Álvarez X et al. Nature. 2021 Jul 15;595(7867):450-454.

Folding of cohesin's coiled coil is important for Scc2/4-induced association with chromosomes. Petela NJ, Gonzalez Llamazares A et al. eLife. 2021 Jul 14;10:e67268.

Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes. Zhang X, Belousoff MJ et al. Cell Rep. 2021 Jul 13;36(2):109374.

Nuclear cGAS: guard or prisoner? de Oliveira Mann CC, Hopfner KP. EMBO J. 2021 Jul 12:e108293.

Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity. Gupta TK, Klumpe S et al. Cell. 2021 Jul 8;184(14):3643-3659.e23.

Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants. Xu J, Xu K et al. Nature. 2021 Jul 8;595(7866):278-282.

Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs. Kern DM, Sorum B et al. Nat Struct Mol Biol. 2021 Jul;28:573–582.

Structural basis of GABAB receptor-Gi protein coupling. Shen C, Mao C et al. Nature. 2021 Jun 24;594(7864):594-598.

The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6. Feng X, Noguchi Y et al. Nat Commun. 2021 Jun 23;12(1):3883.

Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Bhatt PR, Scaiola A et al. Science. 2021 Jun 18;372(6548):1306-1313.

Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT. Jiang Y, Benz TL, Long SB. Science. 2021 Jun 11;372(6547):1215-1219.

Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia. Asarnow D, Wang B et al. Cell. 2021 Jun 10;184(12):3192-3204.e16.

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes. Voss WN, Hou YJ et al. Science. 2021 Jun 4;372(6546):1108-1112.

Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11. Fedry J, Hurdiss DL et al. Sci Adv. 2021 Jun 2;7(23):eabf5632.

Structure and dynamics of a mycobacterial type VII secretion system. Bunduc CM, Fahrenkamp D et al. Nature. 2021 May 20;593(7859):445-448.

Structure of human telomerase holoenzyme with bound telomeric DNA. Ghanim GE, Fountain AJ et al. Nature. 2021 May 20;593(7859):449-453.

Cork-in-bottle mechanism of inhibitor binding to mammalian complex I. Chung I, Serreli R et al. Sci Adv. 2021 May 14;7(20):eabg4000.

Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins. Dang HV, Cross RW et al. Nat Struct Mol Biol. 2021 May;28(5):426-434.

Structural insights into preinitiation complex assembly on core promoters. Chen X, Qi Y et al. Science. 2021 Apr 30;372(6541):eaba8490.


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