Chemical Knowledge

• determination of atom types in arbitrary molecules, including non-standard residues
• ability to add hydrogen atoms
• high-quality hydrogen bond identification
• selection of atoms/bonds by element, atom type, functional group, amino acid category
• interactive bond rotation, distance and angle measurements

Mutations that inactivate the tumor suppressor p53 are found in over 50% of human cancers, and most of the cancer-associated mutations are within its DNA-binding domain. The image shows a tetramer of the p53 DNA-binding domain complexed with DNA (Protein Data Bank entry 2ac0). The tetramer subunits are shown as light blue, green, orange, and yellow ribbons, with red spheres marking several major "hot spots" of mutation. The DNA is shown in purple and blue. (More samples...)