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Read-write mechanisms of H2A ubiquitination by Polycomb repressive complex 1. López VG, Valencia-Sánchez MI et al. Nature. 2024 Dec 19;636(8043):755–761.

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma. Chen YJ, Iyer SV et al. Nature. 2024 Dec 12;636(8042):466-473.

Active-reset protein sensors enable continuous in vivo monitoring of inflammation. Zargartalebi H, Mirzaie S et al. Science. 2024 Dec 6;386(6726):1146-1153.

DMSO might impact ligand binding, capsid stability, and RNA interaction in viral preparations. Wald J, Goessweiner-Mohr N et al. Sci Rep. 2024 Dec 6;14(1):30408.

Nucleosome flipping drives kinetic proofreading and processivity by SWR1. Girvan P, Jalal ASB et al. Nature. 2024 Dec 5;635(8041):251–257.

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October 14, 2024

Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable starting Monday, Oct 14 10 AM PDT, continuing throughout the week and potentially the weekend (Oct 14-20).

August 1, 2024

Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable August 1, 3-6 pm PDT.

July 16, 2024

Chimera production release 1.18 is now available. See the release notes for details.

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Upcoming Events

Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

2D labels and arrows

2D Labels and Arrows

Text, symbols, and arrows of multiple colors and sizes can be added to the Chimera display using the 2D Labels tool or the command 2dlabels. These annotations are drawn “in the plane of the screen” in front of any displayed objects and do not move when the objects are moved. 2D labels and arrows are included in saved images and movies, and can be faded in or out over a specified number of frames.

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Gallery Sample

Peroxiredoxin Wreath

Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.

See also the RBVI holiday card gallery.

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