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Parental histone transfer caught at the replication fork. Li N, Gao Y et al. Nature. 2024 Mar 28;627(8005):890–897.

Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Ying W, Wang Y et al. Science. 2024 Mar 22;383(6689):eadj4591.

Flexibility of binding site is essential to the Ca(2+) selectivity in EF-hand calcium-binding proteins. Lai R, Li G, Cui Q. J Am Chem Soc. 2024 Mar 20;146(11):7628-7639.

Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements. Finci LI, Chakrabarti M et al. Commun Biol. 2024 Mar 2;7(1):260.

Activation of human STING by a molecular glue-like compound. Li J, Canham SM et al. Nat Chem Biol. 2024 Mar;20(3):365-372.

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News

October 30-31, 2023

Planned downtime: The Chimera and ChimeraX websites and associated web services will be unavailable Oct 30 8am PDT – Oct 31 11:59pm PDT.

April 19, 2023

Chimera production release 1.17.1 is now available, fixing an issue with 1.17 for Windows and Linux. See the release notes for details.

April 13, 2023

Chimera production release 1.17 is now available. Updating is required to keep using the tools that run Blast Protein, Modeller, and multiple sequence alignment with Clustal Omega or MUSCLE, as these will soon stop working in older versions. See the release notes for details.

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Upcoming Events

Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

Blast Protein

The Blast Protein tool performs a blast or psiblast search of pdb or nr for sequences similar to a query, using a Web service hosted by the UCSF RBVI. The query can be:

  • a chain from a structure open in Chimera
  • a sequence pasted as plain text
  • a sequence from an alignment in Multalign Viewer
The output is a list of hits, from which all or a user-chosen subset can be retrieved:
  • as a pseudo-multiple sequence alignment (a consolidation of the pairwise alignments of individual hits to the query), automatically shown in Multalign Viewer
  • as structures (for hits from pdb), automatically superimposed according to the pseudo-multiple alignment

(More features...)

Gallery Sample

Wasabi Receptor

The image shows the structure of the human TRPA1 ion channel (wasabi receptor) determined by electron cryo-microscopy, Protein Data Bank entry 3j9p. The four subunits of the tetramer are shown as ribbons in different colors over a dark-to-light gradient background. (More samples...)


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